I started taking ortho-tricyclin lo in november of 2004. I had side effects such as irritability, changes in appetite, mood changes, fatigue and lethargy...I basically had all the side effects. I talked to my gyno and she said to give my body a few months to adjust...So I did. I took it for a while longer and still not better, so I went back and talked to her. She switched me to mircette and i've been on it for two weeks, and I still feel all the side effects, and the irritability and mood changes are worse. I don't know where to go next, or how long I should wait to see if it gets better. I'm fighting with my boyfriend because i'm so irritable and I don't want to! I love him very much and i've got to get this sorted out! Please help me, if you have any suggestions.......