Personality changes are often an indication of chemical dependancy on an addictive substance. Increased tolerance (decreased effectiveness - and needing to take more of a medication) are some other symptoms.

As the dependancy on a substance progresses, the pain threshold drops, causing the person to perceive seemingly normal discomforts and problems as unbearable disasters. This impacts the person's physical, emotional, and spiritual sense of well-being

When a person does not take their medication they can become very irritable or angry. However, there is a distinction between chemical dependance and addiction. For more information check out the Addiction & Recovery Forum...