School of pharmaceutical sciences,
university sains malaysia, 11800 penang,
malaysia.
The plant typhonium flagelliforme
(araceae), commonly known as the 'rodent
tuber', is often included as an essential
ingredient in various herbal remedies
recommended for cancer therapies in
malaysia. Various extracts prepared from
either the roots, tubers, stems or leaves
were tested for cytotoxic activity on
murine p388 leukaemia cells using the mtt
assay method. Both the chloroform (ic50 =
6.0 microg/ml) and hexane (ic50 = 15.0
microg/ml) extract from the 'roots and
tubers' exhibited weak cytotoxic activity.
The hexane extract (ic50 = 65.0
microg/ml) from the 'stems and leaves'
exhibited weaker cytotoxic activity than
the chloroform extract (ic50 = 8.0
microg/ml). Although the juice extract
from the 'roots and tubers' is frequently
consumed for cancer treatment, it
exhibited poor cytotoxic activity.
Further analysis using an amino acid
analyser revealed that the juice extract
contained a high concentration of arginine
(0.874%). A high tryptophan content
(0.800%) was confirmed by nmr and hplc
analysis.
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This page was last updated on June 11, 2008
