check with your dermatologist to see if you might have weber-cockayne, a form of endermolysis bullosa, an inherited genetic disorder. in severe forms it can cause really unpleasant stuff, but the weber-cockayne version can have onset in youth or adulthood and seems to mostly lead to blistering on the hands and feet.
i am waiting to have a biopsy to find out if this is indeed what i have, but my dermatologist presented this as a likely candidate since i don't have itching (which would be more indicative of eczema).
Unfortunately W-C is not curable, but my understanding is that there are topical and other treatments that can help you to better manage and soothe the blistering and peeling.
hope this helps some other folks out there! it took me a few dermatologists before i found one who was really patient and concerned enough to listen to my symptoms. W-C seems to occur only in about 1 in every 30,000 - 50,000 individuals, so if you live in a small town, your dermatologist may not have it on his/her radar screen.