I took Zoloft 50mg and it sedated me I was in la la land but felt great...soon as they upped the dose, I was sick as a dog...then, I took Lexapro 10 mg and I felt like I was on an illegal drug, I was sooo sick, legs trembling, sweats, anxiety, turns out it was too strong for me and I had every side effect, but my mother in law takes it and loves it, works great for her. So, everyone is different, you have to find the right pill that works for you. Tell your Dr. if you are sensitive to med's, that's important. One bad experience like these and I'm done. w/those meds...I don't give it another chance. Now, I'm going on Cymbalta 30mg today, we'll see what that does, I'm crossing my fingers. I can't wait to overcome this majoe depression...what a horrible and uncontrollable feeling! God help all of us.