Zoloft and lithium were life savers for me - plus finding the right therapist. I'm off the lithium, but i'm still on the zoloft. Only side effect has been weight gain, but if I have to choose between thin and miserable versus fat and happy - guess which one I picked!
Had 1 dosage increase about 2 years ago due to financial and marrital worries. Have been doing fine since then.
Meds are so individual - you have to try it and see what works best for you. With psych meds, you have such a long time for theraputic effects to show up and then you have a long weaning off period, too, if you switch drugs. Keep looking and remember your behavior therapy stuff, too!