Hello there! I've been formally dx with bi-polar for 10yrs. Now and started out on litium and zoloft. I /we (meaning my md and i) had troubles getting my levels smooth. I went to see a neurologist, and she changed my litium (thank god-i didn't find that med. Beneficial at all) to valporic acid and the dose being 250mg. Am.-noon-hs each time. This med. Helps me with my "lows" and we also (my md and i) changed my antidepressant to effexor -dose being 75mg. In am. I'm on a 4yr. Stable "ride"ever since. I find these meds. Very effective obviously for me anyway. Before this, my last manic phase I was rx seroqual at high doses to keep me pretty much sedated until I wasn't "high". This took about 6wks. Then we slowwly "brought me up" to level again. The starting dose was 25mg. In am and 100mg. Pm, then we went to 50mg. In am. And 150mg. In pm, then 200mg. In pm. In all honesty, I started to not takeing the am 50mg. Dose simply because I wasn't getting up out of bed until 3:00pm. And I was simply "tired" of being so tired and doing nothing but sleeping. This went on over a period of 3months before I leveled out. So like I mentioned earlier, i've been stable now 4yrs. I only work part-time which helps, I work out (even when I don't want to, stretching at least) I meditate and do yoga. This is my regimine very simple, and it works great. In ten yrs. I've never been on any of the meds. You've mentioned. Read about the two I take, and maybe they may be appropriate for you. Would't it be nice if we all suffering from bi-polar could just take the same med. And it work great!!