Picamilon is gaba and niacin (b3) fused together in same molecule, which allows gaba to easily pass through the blood-brain barrier, as niacin acts as the carrier (just taking gaba usually doesn't work, since gaba doesn't easily pass through the bb barrier). I saw this info from another board and checked it out. Within a couple days my anxiety went away. Recent evidence suggest that panic disorders and anxiety are from not only a lack of serotonin, but a gaba deficiancy, also. Gaba is a neural inhibitor, so this makes sense. Most anxiety sufferes have an overactive mind and with low gaba levels your brain can't possibly settle down enough to remain calm.

Picamilon is an mao inhibitor, too, so it is effective for depression.

In small doses it produces a sedative effect, but not drowsiness, like valium (btw, valium is a gaba re-uptake inhibitor - that's how it works). In larger doses (200-300mg/day) it energizes you, yet calms you down. Pacamilon is considered a nootropic and will increase cerebral blood flow significantly, so there are cognitive advantages, too. Basically, it's pretty amazing sh*t.

Check out: smart-nutrition.Net for more info.

Do your homework on this, because I believe gaba defficiancies are the missing link in anxiety/panic/depression disorders. If fact, many researchers will now say that it's one of the key neurotransmitters connected to these mental disorders, along with serotonin, dopamine, and norepinephrine. I know gaba played a huge role in my own anxiety and depression.