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AlisBaby

New User, Becoming EHEALTHy
Joined: 17 Aug 2004
Posts: 19
Location: Virginia
Newbie With Questions
Posted: 08-17-04 17:35pm

Hi there... I'll try to make a long story short. I'm 39 and have been ana+ for about 2 years - first at 1:80, then 1:160 several months later, and now 1:320. My other symptoms are: arthralgia, malar rash on my face, raynaud's, photosensitivity, and recurrent occult pregnancy loss (just diagnosed).

My reproductive endocrinologist just ordered some tests because he thought I might have autoimmune or alloimmune issues relating to maintaining pregnancy. Here are my most recent results:
ana 1:320
anti-dna (ds) 34
rnp 16
sm 30
sjogren's ssa 21
sjogren's ssb 5

my lupus anticoagulant results were (reference range):
pt 14.9 (11.9 - 14.5)
ptt-la 57.7 (0-52)
aptt 39.9 (23.4 - 36.4)
aptt 4:1np 38 (23.4 - 36.4)
thrombin time 18.5 (<1Cool

i also tested positive for anti-phosphocholine igm and borderline for anti-phosphoserine igm on my anti-phospholipid panel.

My main question is this: what is considered a high-titer ana? I keep hearing different things. For instance, the rheumy I saw said he doesn't become concerned until the test reaches 1:1280 (but then this was the guy whose first question to me was, "so, is everything okay at home?")

input, ideas, similar experiences? I do know that I will not go back to him -- i'm thinking of finding a female rheumy.

Thanks!
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62pjm63

New User, Becoming EHEALTHy
Joined: 18 Aug 2004
Posts: 3
Location: Orlando
Newbie With Questions
Posted: 08-18-04 20:11pm

Hi, alisbaby

i am not sure what my tests showed at the time but I lost two pregnacies one at 17 weeks and the other at 21 weeks. What type of problems exactly? You can email me privately if you like.

I had two healthy children and then I got divorced and remarried and six years later got pregnant and after I lost my first one that is when all the tests began. I was only dianosed ana positive and they told me that if I got pregnant again to have a rheum md and a high risk pregnancy md which I did and I was monitored so closely but becuase of my lupus I lost my second.

This by no means will happen to you as you can see from reading this forum we are all so different with our symtpoms. Can you tell me what kind of information you are looking for and maybe I can give you better advice.

62pjm63
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AlisBaby

New User, Becoming EHEALTHy
Joined: 17 Aug 2004
Posts: 19
Location: Virginia
Specifically...
Posted: 08-19-04 18:28pm

Specifically, I was just looking for input on what your docs thought was "high titer" ana. The first rheumy I went to said he didn't get concerned until it reached 4 digits, but I just read elsewhere that 1:320 is considered active disease and 1:640 means tissue/organ damage is imminent. I can't find any support of the latter claim - just found the reference on the one website.

I'm wondering if I will get a diagnosis with an ana of 1:320, with the positive phospholipids, the arthralgia, mild malar rash, raynaud's, migraines, fatigue, mouth and nose ulcers... Seems I fit the bill, huh?
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