I posted a while back how I turned around my myelofibrosis within a very short period using vitamin c and selenium and I have been asymptomatic for approx 1.5
years.
Those MF sufferers will find hope with the following extract that medical research in 2002 (yes, nine years ago) it was discovered that vitamin c will supress the Jak 2 inhibitor gene that is suspected of triggering myelofibrosis.
I might add that major cancer institutes are rushing to find a supressor for the JAK 2 gene in the hope of making a lot of money. Why, when it is readily
available now.
Read the extract and for those who want the full medical article to give to your oncologists, let me know and I will forward this to you. Don't be surprised that the oncologists will Pooh Pooh the research as there is no money in vitamin c injections, but there is in administering chemo drugs and bone marrow
transplants -
"HEMATOPOIESIS
Vitamin C inhibits granulocyte macrophage�colony-stimulating factor�induced signaling pathways
Juan M. Caôrcamo, Oriana Boôrquez-Ojeda, and David W. Golde
Vitamin C is present in the cytosol as ascorbic acid, functioning primarily as a cofactor for enzymatic reactions and as an antioxidant to scavenge free radicals.
Human granulocyte macrophage�colonystimulating
factor (GM-CSF) induces an increase in reactive oxygen species (ROS) and uses ROS for some signaling functions.
We therefore investigated the effect of vitamin C on GM-CSF�mediated responses.
Loading U937 cells with vitamin C decreased intracellular levels of ROS and inhibited the production of ROS induced by GM-CSF. Vitamin C suppressed
GM-CSF�dependent phosphorylation of the signal transducer and activator of transcription 5 (Stat-5) and mitogenactivated protein (MAP) kinase (Erk1 and Erk2) in a dose-dependent manner as was phosphorylation of MAP kinase induced by both interleukin 3 (IL-3) and GM-CSF in
HL-60 cells. In 293T cells transfected with alpha and beta GM-CSF receptor subunits (GMR and GMR), GM-CSF�induced phosphorylation of GMR and Jak-2 activation was suppressed by vitamin C loading. GM-CSF�mediated transcriptional activation of a luciferase reporter
construct containing STAT-binding sites was also inhibited by vitamin C.
These results substantiate the importance of ROS in GM-CSF signaling and indicate a role for vitamin C in downmodulating GM-CSF signaling responses. Our findings point to vitamin C as a regulator of cytokine redox-signal transduction in host defense cells and a possible role in controlling inflammatory responses.
(Blood. 2002;99:3205-3212)
é 2002 by The American Society of Hematology
For the full medical paper in pdf form, I can be contacted via the contact form at
www.ecobites.com - Reference Dalt/JAK 2 inhibitor gene.