Omega-3 Fatty Acids For Bipolar Disorder. Posted: 06-16-04 17:39pm
Omega-3 fatty acids for bipolar
disorder.
Polyunsaturated fatty acid deficit in
patients with bipolar mania. Chiu,
chih-chiang; huang, shih-yi; su, kuan-pin;
lu, mong-liang; huang, ming-chyi; chen,
chiao-chicy; shen, winston w. School of
medicine, taipei city psychiatric center,
laboratory of biological psychiatry,
taipei medical university, taipei, taiwan.
European neuropsychopharmacology (2003),
13(2), 99-103. Coden: eurne8 issn:
0924-977x. Journal written in english.
Can 138:399812 an 2003:209391 caplus
(copyright 2004 acs on scifinder (r))
abstract
the aim of this study is to test the
hypothesis that there is a depletion of
polyunsatd. Fatty acids of erythrocyte
membranes in patients with bipolar
disorder and to connect the previous
therapeutic and psychoimmunol. Findings.
Fatty acid compns. Of erythrocyte
membranes in 20 bipolar manic patients and
20 healthy controls were analyzed by
thin-layer chromatog. And gas chromatog.
The major finding was significantly
reduced arachidonic acid (20:4n-6) and
docosahexaenoic acid (22:6n-3) compns. In
bipolar patients as compared to normal
controls with p values of 0.000 and 0.002,
resp. There were no differences in total
omega-3 and omega-6 polyunsatd. Fatty
acids. This abnormality may be related to
the mechanisms of action of mood
stabilizers and the previous findings on
the abnormal psychoimmunol. Of patients
with bipolar disorder. Larger sample
sizes of medicated patients or drug-free
manic, well-controlled designs on the diet
and smoking, and fatty acid compn.
Measurements during full remission after
the index episode are warranted in future
studies.
