Hello everybody, I write this post because I was diagnosed with pseudo cholinesterase deficiency after a complication regarding anesthetic drugs, in a surgical operation. I visited many doctors in Argentina, my country, but they failed to give me a list of substances and medications that i should avoid due to this condition. I hope that perhaps somebody here could give me the names of the drugs that he or she knows in order to build this list. Also, if somebody knew which nutritional deficiencies or other conditions that could cause this disease, it would be really helpful for me read about them. The main thing however, would be to have that list of drugs to be avoided, since I'm really really scared that I could get exposed to them and suffer a terrible damage, or perhaps even death . Thank you very much to everybody, and good luck, ill be waiting for your answers
PD: which medical specialty studies this disease (eg: endocrinology, serology, etc)
Avoid choline ester compounds, such as succinylcholine, mivacurium, procaine, novacaine or cocaine. You should warn members of your family that they may also have this condition and should discuss it with their physicians. Family members (particularly teens and young adults) should be warned to avoid recreational use of cocaine
Drugs to avoid:
Succinylcholine: (Quelicin & Anectine) A dose that would paralyze the average individual for 3 to 5 minutes can paralyze the enzyme deficient individual for up to 2 hours.
Mivacurium: muscle relaxant
Pilocarpine: used to treat dry mouth
Drugs containing Butyrylcholine: It can be used to treat exposure to nerve agents, pesticides, toxins, etc
Drugs containing Huperzine A and Donepezil: used to slow the progression of Alzheimer's disease
Drugs containing Propionylcholine and Acetylcholine
Drugs containing Parathion: an agricultural pesticide
Procaine drugs: (Novocaine): local ester anesthetic that can be used during dental and surgical procedures, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anesthetic. An amide would be recommended
Mostly, you need to mention your condition to any healthcare provider and absolutely to the anesthesia team prior to surgery. Additionally, if anyone in your family has surgery they should mention thta a relative has been diagnosed with this as it is passed on genetically.