Alcohol, street drugs (ecstasy, cocaine, hashish, amphetamines, magic mushrooms), medication (steroids, certain blood pressure tablets and anti-Parkinson drugs') can all cause depression or mania in people who are predisposed to mood-swings.

Have you been diagnosed bipolar already?

Wish I could help, but I've never done those drugs.

from my experiences, yessir

I can tell you that I bugged out on shrooms and became manic on PCP and Ketamine

It goes without saying...

Any form of hallucinogens and/or mind alterring substances, messes with your neural pathways by either blocking them or allowing more stimulis to go through than what is supposed to. That's why mind alterring substances makes you "High"...which could also be described as Manic.

This is a protection method of the plant to stop animals from eating it. Some thorn trees in the African Savannah has been proven to start secreting cianide if an animal eats too much of it (Giraffes only eat for a couple of minutes from a specifc tree and then moves on as the tree becomes toxic)

In the case of bi-polarism, these neural pathways is naturally disrupted by some chemical in-balance in the brain that manages the flow of stimuli. Therefor, these same substances gets used to alter the flow of stimuli. Obviously, this a very fine balancing act and most medication will, ten to one, make you lean towards either the manic or depressive side depending on the person.

Don't know why I rambled on like this about the subject, but that's my take on it

Hi there... I think its obvious that shrooms could cause manic symptoms to appear. I used to shoplift DXM from stores to level out my mood when I was manic and it just really made me a zombie, right now I steer clear of anything except weed.

I wasn't diagnosed at the time, so I didn't realize what was happening to me, but back when I was about 19 or 20 I took some psylocybin mushrooms with some friends. The trip turned bad real quick. I started ranting, "This is it. There's nothing else. You're a kid, you go to school, you get married, have kids, and that's it. There's nothing else. We're all trapped, trapped in the pattern. There's nothing else. You're a kid, you go to school...etc." On and on, for hours, until my friends left me alone, confused at how to deal with me. When the affects finally wore off, the mantra continued in my head. I couldn't make it stop. I think this was my sophmore year in college, and I remember pacing my dorm room for several hours every night with the matra repeating itself over and over again in my head. I was scared to go to class, I was scared to see people, so I was scared to leave my room. It then got worse, suicidal thoughts started spinning through my head. And I didn't understand. I tried to counteract the mantra with another, more positive statement, "I have a great family, good friends, a nice life, I should be happy." It didn't work. The pervasive sadness and unending mantra lasted for several months. It was only a year later I would have my first hospitilization, leading to a bipolar diagnosis. So, yeah, I think hallucinogens can trigger an episode.