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Mental Health > Bipolar Disorder Forum > Warning: Champix/chantix + Bipolar = Disaster
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Q: Warning: Champix/chantix + Bipolar = Disaster
asked by: purplesage on October 22nd, 2007
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I'm bipolar and have been taking 200mg Lamictral and 25mg Seroquel for about 2 years now, with some success. Recently I decided to quit smoking and to make it more likely that I'd succeed I started taking a new quit-smoking medicine, known as Champix or Chantix.

After 5-7 days I started having the manic trip of my life, stronger than any I had ever experienced. I spent a month in a state of total euphoria. And this in spite of the fact that my mania normally expresses itself as rage and irritability -- this is only the second classic manic episode I've had in my LIFE (the first was triggered by a SSRI). Jesus was I happy! And since I had virtually no experience with euphoric mania, I was clueless.


Of course, everything came crashing down, and I'm dealing with a brutal depression and more intense suicidal ideation than I can remember ever having. EVER. So be warned, bipolars - avoid Champix / Chantix like the plague. Better to smoke yourselves to death -- you'll probably live far longer that way. (NOTE: Of course this drug is not contraindicated for bipolar - it's new, and drug companies invariably do trials on people who are healthy in every way)
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Jake3463
replied on October 22nd, 2007
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Ditto
Same thing happened with me. I'm on Abilify and Lamictal. Started having wierd dreams and than I started to get paranoid and have racing thoughts. I don't think they tested the drug for interactions with bp medications.
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abnrmlmind
replied on October 22nd, 2007
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i enjoy euphoric episodes but i tend to make problems for myself. abilify... doctors give that to people that have schitzophrenia also. i dunno what lamictal is, almost sounds like something youd put up your bum. just because champix / chantix did that to you doesnt necessarily mean it will to others, everyone is different.
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Jake3463
replied on October 23rd, 2007
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Mixxing Drugs
You mix drugs you might have a reaction. Nothing against Chantix but I doubt the standard round of test they did didn't include people on bipolar medication. Give it time and we'll be on the list of possible interactions.
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Catecholamine
replied on November 13th, 2007
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Oh, you might do well on a kappa-opioid agonist. It down-regulates acetylcholine receptor mRNA, inhibits the release of both norepinephrine and acetylcholine, and it should have an overall stabilizing effect on your moods. It might also reduce your chances of developing propensities for alcoholism. No promises. I'm just a mad sage. I wouldn't let anyone suffering from bipolar disorder within nine yards of Chantix, though. It would make you kids climb the walls. I don't know why it wasn't immediately contraindicated.

Keep the euphoric trips under control. Whenever I let these things get out of hand, I do an icarus, and daaaaaaaang it hurts when I fall. I discovered a few years ago that, if I can keep the manic episodes in check, I can nearly altogether escape the depression and still stay on a constant life high. It's so great. I don't know if I'm bipolar, though. It's cyclothymia at the very least. Me and my tangents.

The OP is correct. Avoid chantix like the plague. It's wonderful for most people, poison for someone affected with bipolar.
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puzzld
replied on November 20th, 2007
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i take chantix and a list of other meds, for bipolar, and have no quarrel with it. although, it does make me extremely nauseous if i haven't eaten first. that sucks for you.... i'm trying to quit right now, too, with little success i'm afraid. good luck!
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Catecholamine
replied on November 23rd, 2007
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You're taking it FOR bipolar? Bah, now I'm going to have to revise my conclusions again. Different strokes, different folks, I guess.
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puzzld
replied on November 25th, 2007
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ah... no sorry mistyped... thought, brain cloud. NOT taking chantix for bipolar; i'm taking it to assist in my efforts to quit smoking. i probably meant 'in conjunction with' bipolar meds, as discussed on this forum category topic whatever.

as i'm reading this thread again i'm remembering taking chantix while taking seroquel 600mg/day, lamactile 1mg/day, cymbalta 60mg/day and ativan 6mg/day. and i was just, 2 weeks ago, diagnosed with bipolar 1 as a result of who knows what; first manic episode just before a fight with mom to panic attack to full blown hyperventilation. BUT, i don't think taking these meds together has caused my ill temper and terror because i felt this way long before chantix.

it is true... different strokes for different folks

a dr overdosed me on paxil once.

hang in there.... this too will pass.
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pebbles07
replied on November 30th, 2007
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cold turkey is the safest way i think
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Pellipar1
replied on February 20th, 2009
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Chantix/Champix Depression
I do not have any history of depression, and the same thing happened to me.

Started taking, felt very happy, after about 10 days started feeling more and more depressed.

Took me a while to work it out as no history of depression, but everything seemed bad and I felt miserable. Not until I stopped taking that I felt better and realised how bad it had made me feel.

Ontop of that, I failed to quit smoking and it makes you feel incredibly nauseous the whole way through....not advised.
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Phocks
replied on February 20th, 2009
Experienced User
Hey guys.

I feel your pain on the champix thing.

I have a history of depression but any major episodes were few and far between. I would have minor depressive episodes every few months and major ones say every 2 years.

Since going on Champix late last year I have been on a major non stop roller coaster ride. I am constantly depressed and suicidal. Found out that I fit the mould for 2 personality disorders and am now waiting for my appointment to start talking about bipolar.

My understanding is that champix is great for people with sound mind (I did give up on it myself immediately). But us crazy people are taking a risk with it.

Take care all.
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guccigirlaccessories
replied on May 28th, 2009
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chantix and lamictal
I am on week five of chantix. I also take 200 mg of lamictal, and 30 mg of celexa. While I dont really want to smoke, i feel like im going to jump out of my skin. Im depressed (which i can handle for a while if i can quit)so the depression, with the anxiety, (i am hyper and bipolar, lol. Here is the thing, I have two other family members that quit, they are using nothing and have the same side effects. My brother is a week ahead of me. I think depression is a huge side effect of quitting smoking in general.

Kelly h.
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zandra_rose
replied on August 5th, 2009
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I have never been diagnosed with any form of bi-polar disorder. But am aware of this and unuderstand it due to the nature of my job role.

I am currently on Champix and in my 4th week. This is my second time on Champix, first time I quit smoking for 6 months. And experienced similar effects to as I am now.

I came across this thread after googling 'champix related to euphoria' as I am amazed by the effect the drug seems to have on me. not only stopping smoking, but my general attitude too.
I have never been so alert, organised, switched on, happy as when I am on these pills, I go on mad cleaning sprees till 6am, manage to be super productive at work and go to the gym 5 times a week. I love it, until this weekend I was away and forgot to take the pills with me. Managed not to smoke, but 3 days off Champix and i am finding myself withdrawn. I am lethargic, sad and appear to be what I would describe myself as slightly depressed.

Has anyone else experienced these sort of behaviours on Champix?
When I last came off Champix I was slightly down, I put this on being that I had stopped smoking.
I have started taking champix again, and fear what will happen when i come off it when my course is finished.
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