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Cancer > Colon Cancer Forum > Biopsy False Negative Possible?
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Q: Biopsy False Negative Possible?
asked by: Tim123 on October 19th, 2007
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Hi Everyone,

I'm new to this forum and to cancer and thought to call upon the experience of the group to answer a question.

My Mother was recently diagnosed with colon cancer, at least we think she was. Her blood count was low enough to suggest internal bleeding. The did a colonoscopy and found a 4 cm polyp. The doctor who did the colonoscopy has 30 years experience and says that visually it appears certain that the polyp is cancerous and needs to be removed surgically. But then the biopsy results came back negative for cancer.

So has anyone encountered a situation where a biopsy result was negative, but the polyp was still cancerous? Is it possible that the biopsy was taken from a non-cancerous area of the polyp and that cancer is still present elsewhere?

I've read that any polyp that reaches 2 cm or great is at great risk of becoming cancer if not already. So regardless, the polyp still needs to be removed. Surgery is booked. It would offer a bit of peace of mind though if we were to find out that the biopsy result is conclusive and that, although my mom has a 4 cm polyp, she does not have cancer.

Thanks kindly, for reading my post and offering any opinions.

Warm regards,

Tim
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MandMs
replied on October 22nd, 2007
Extremely eHealthy
Is her doctor considering making another biopsy?
Does she have somebody in her close family with colon polyps or colon cancer?
Do you know the exact description of her polyp?
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Tim123
replied on October 23rd, 2007
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Re: Biopsy False Negative Possible?
Hi MandMs,

Our family does not have a history of colon cancer/polyps. We don't know more about the polyp other than that it's 4 cm. I've read before that anything greater than 2 cm will likely become cancer if not already. So mom is proceeding with the plan for surgery, currently booked for Nov. 8th.

Thanks for your reply,

Tim
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MandMs
replied on October 26th, 2007
Extremely eHealthy
Biopsy results can be false negative due to microcancer areas in the polyp.
You are right that any polyp that's greater than 2 cm has a bigger chances to become malignant.
So, having a surgery she 'll have reduced chances for malignant appearance.
She'll need to make frequent check up.
Wish you all the best to you and your family!
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Tim123
replied on October 26th, 2007
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Re: Biopsy False Negative Possible?
Thanks again, MandMs! Mom is preparing for surgery.
We are all very positive that surgery will be successful
and mom will recover fully. Really appreciate your
opinions and those of others.

Blessings to everyone.

Tim
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MandMs
replied on October 29th, 2007
Extremely eHealthy
I'm gonna think of you and your mum!
I'm sure she'll be fine.
Please, inform us here about your mum's surgery and days after.
Waiting for your post!
Take care!
Marija
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Woodrow
replied on November 3rd, 2007
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Pathology Routine?
My friend survived Stage III colon cancer. Please keep us informed...even though it seems you are in fine medical hands.

I'm not a medical professional, but it seems like common sense to me that any excised tumor would be examined microscopically for cancer. Certainly, any such report would trump a biopsy, whose statistical merit is fundamentally questionable, as you have sensibly discerned already...and which point Marija has affirmed on Oct. 26.

I would suggest that you insist that a sizable sample of tumor be preserved...for examination of the mutant, tumorous DNA, if necessary, in the future. This can have a bearing on appropriate chemotherapy.

I realize that you, like many others, are consumed with your mother's situation. Please remember to tell us how it works out. Many others might benefit.

It is my non-professional opinion that familial predilection towards colonic carcinomas is negligible, when it manifests in later life. Dr. Bert Vogelstein has published on tumorgenesis. It is a long long story. No...cheeseburgers have not been proven to cause it, either. There are countless quacks hawking prophylaxes and cures. Nothing compares to colonoscopy; this disease is almost always preventable. There are some remote risk factors to colonoscopy that spook some prospective patients, seemingly primarily men as opposed to women.
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gwb234
replied on November 9th, 2007
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False Negative Biopsy
Hi,
I am in exactly the same situation with surgery scheduled for next week. I have a 4 to 5 cm tumor in the colon that has come back negative on 2 sets of biopsies. My research has found that 40% of these types of tumors do have cancer. Biopsies of these types of tumors can give a false negative result 25% of the time because only part of the tumor has turned to cancer and the biopsy missed that part of the tumor. The question for me is if there is cancer would it be more likely to be at an early stage which is very curable. Please post how your mom is doing. I know it is an anxious time and I am hoping
for the best for her.
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2cs
replied on April 22nd, 2008
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False Negative Biopsy
My mom at 88 is in the exact same situation. Doctor declares a malignancy and will not change even though biopsy of large mass came back negative. How did the surgery go for your Mom and was she near my Mom's age?
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