Does Dht Effect Fibromyalgia Posted: 09-05-07 21:19pm
I have spoken to many women who have had a
hysterectomy and most have complained of
thyroid problems, weight gain, upset
stomach, IBS, hair loss, along with other
symptoms and most all have been diagnosed
with fibromyalgia. I was reading about how
Propecia is used to treat fibrosis and
this is what it said
**********(Androgenetic alopecia (AGA) is
a dihydrotestosterone (DHT)-mediated
process, characterized by continuous
miniaturization of androgen reactive hair
follicles and accompanied by
perifollicular fibrosis of follicular
units in histological examination.
Testosterone (T: 10(-9)-10(-7) M)
treatment increased the expression of type
I procollagen at mRNA and protein level.
Pretreatment of finasteride (10(- M) inhibited the
T-induced type I procollagen expression at
mRNA (40.2%) and protein levels (24.9%). T
treatment increased the expression of
transforming growth factor-beta 1
(TGF-beta1) at protein levels by 81.9% in
the human scalp dermal fibroblasts (DFs).
Pretreatment of finasteride decreased the
expression of TGF-beta1 protein induced by
an average of T (30.4%). The type I
procollagen expression after pretreatment
of neutralizing TGF-beta1 antibody (10
mug/ml) was inhibited by an average of
54.3%. Our findings suggest that T-induced
TGF-beta1 and type I procollagen
expression may contribute to the
development of perifollicular fibrosis in
the AGA, and the inhibitory effects on
T-induced procollagen and TGF-beta1
expression may explain another possible
mechanism how finasteride works in AGA)
***** so I am wondering if there is a link
of DHT and fibromyalgia and if finasteride
may help.****** let me know if you have
???? or answers.
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M) inhibited the
T-induced type I procollagen expression at
mRNA (40.2%) and protein levels (24.9%). T
treatment increased the expression of
transforming growth factor-beta 1
(TGF-beta1) at protein levels by 81.9% in
the human scalp dermal fibroblasts (DFs).
Pretreatment of finasteride decreased the
expression of TGF-beta1 protein induced by
an average of T (30.4%). The type I
procollagen expression after pretreatment
of neutralizing TGF-beta1 antibody (10
mug/ml) was inhibited by an average of
54.3%. Our findings suggest that T-induced
TGF-beta1 and type I procollagen
expression may contribute to the
development of perifollicular fibrosis in
the AGA, and the inhibitory effects on
T-induced procollagen and TGF-beta1
expression may explain another possible
mechanism how finasteride works in AGA)
***** so I am wondering if there is a link
of DHT and fibromyalgia and if finasteride
may help.****** let me know if you have
???? or answers.