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Conditions and Diseases > Fibromyalgia Forum > Does Dht Effect Fibromyalgia
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Q: Does Dht Effect Fibromyalgia
asked by: jaovanny on September 5th, 2007
New User
I have spoken to many women who have had a hysterectomy and most have complained of thyroid problems, weight gain, upset stomach, IBS, hair loss, along with other symptoms and most all have been diagnosed with fibromyalgia. I was reading about how Propecia is used to treat fibrosis and this is what it said **********(Androgenetic alopecia (AGA) is a dihydrotestosterone (DHT)-mediated process, characterized by continuous miniaturization of androgen reactive hair follicles and accompanied by perifollicular fibrosis of follicular units in histological examination. Testosterone (T: 10(-9)-10(-7) M) treatment increased the expression of type I procollagen at mRNA and protein level. Pretreatment of finasteride (10(-Cool M) inhibited the T-induced type I procollagen expression at mRNA (40.2%) and protein levels (24.9%). T treatment increased the expression of transforming growth factor-beta 1 (TGF-beta1) at protein levels by 81.9% in the human scalp dermal fibroblasts (DFs). Pretreatment of finasteride decreased the expression of TGF-beta1 protein induced by an average of T (30.4%). The type I procollagen expression after pretreatment of neutralizing TGF-beta1 antibody (10 mug/ml) was inhibited by an average of 54.3%. Our findings suggest that T-induced TGF-beta1 and type I procollagen expression may contribute to the development of perifollicular fibrosis in the AGA, and the inhibitory effects on T-induced procollagen and TGF-beta1 expression may explain another possible mechanism how finasteride works in AGA) ***** so I am wondering if there is a link of DHT and fibromyalgia and if finasteride may help.****** let me know if you have ???? or answers.
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