I haven't used it, but it is just a combined hormone contraceptive like most other pills. The only difference between it and other pills is that you take the active pills on a 91 day cycle instead of a 28 day cycle. So it has the same common side effects. The more serious ones are listed with the more common (and less serious) ones under that.
I found this on Drugs.com......
What are the possible side effects of Seasonique?
If you experience any of the following serious side effects, stop taking Seasonique and seek emergency medical attention or contact your doctor immediately:
*an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
*possible blood clot in the lung (shortness of breath, coughing up blood, or pain in the chest); the leg (pain, redness, swelling, or numbness of the leg); or the eye (partial or complete loss of vision);
*chest pain or heaviness in the chest (possible heart attack);
*severe headache or vomiting, dizziness or fainting, vision or speech disturbances, weakness or numbness in an arm or leg (may indicate a stroke);
*breast lumps;
*possible liver problems (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue).
Other, less serious side effects may also occur. Continue to take Seasonique and talk to your doctor if you experience
breakthrough bleeding or spotting;
headache;
nausea or vomiting;
breast tenderness;
depression;
changes in weight or appetite;
changes in skin color; or
changes in fit of contact lenses.
Hope that helps!