Join Our Community!
Share
Conditions and Diseases > Gout Forum > Gout From Paxil
Gout is a common type of arthritis and accounts for about 5% of all cases of arthritic condition. But what is gout and what are the stages of this condition?...
Gout manifest for physical reasons...but what puts you at a greater risk of developing the disease? What risk factors should you avoid?...
Gout present symptoms mainly in the joints. Learn which signs to look for, and when you should seek medical help and diagnosis of gout....
Avatar
Q: Gout From Paxil
asked by: stez1970 on August 9th, 2007
New User
I was just informed that I got gout from Paxil. How can the drug Paxil cause gout?
Did you find this post useful?
|
Replies(1)
Avatar
painfree
replied on August 10th, 2007
Experienced User
Here's one theory. One of the known side effects of paxil is somnolence, excessive sleepiness. Any sleep-inducing preparation can cause gout in an indirect way by exacerbating sleep apnea, the condition where muscles in the pharynx relax so much during sleep that they allow the airway to close up repeatedly for prolonged periods. Sleep apnea causes gout by two effects resulting from the lack of oxygen. First, the oxygen-starved cells in the body begin a process of disintegration (catabolism) which culminates irreversibly in their generation of excess uric acid fed into the blood. Second, the percentage of carbon dioxide in the blood is increased, which makes the blood more acidic and hence less able to hold uric acid in solution. As a result, uric acid precipitates from the blood in the form of monosodium urate crystals. When these crystals lodge in a joint, they cause a gout attack.

I had a similar experience when I started using melatonin before bed every night. It took me a while to realize that it was exacerbating my sleep apnea, resulting in renewed attacks of my gout. When I cut out the melatonin, my gout attacks ceased, along with my wife's complaints about my excessive snoring.
Did you find this post useful?
|
Quick Reply
Search