My primary care doctor recently suggested that I start taking Prozac (fluoxetine) for my depression related to menstrual cycle. But I am a little bit hesitant to start taking it because of the list of side effects. In your experience with patients, does Sarafem tend to work better than Zoloft to relieve symptoms of depression related to PMDD? Also, how is Sarafem different than regular Prozac? Is it a lower dose of Prozac? I know that they are both SSRI's, but do any of them work better (with less side effects) for treating PMDD?