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Does Tamoxifen Cause Liver Cancer

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blueskyred

New User, Becoming EHEALTHy
Joined: 13 Jul 2007
Posts: 1
Does Tamoxifen Cause Liver Cancer
Posted: 07-13-07 03:37am

Hi there. My sister in low has a early stage breast cancer and is taking tamoxifen pills. I was doing some research on the net and found out that tamoxifen can cause liver cancer. Is this true ? What is the connection between tamoxifen and liver cancer ? thanks
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MandMs

Extremely EHEALTHy
Joined: 26 Jan 2007
Posts: 1963
Location: Strumica, Macedonia
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Posted: 09-13-07 05:50am

Hi!
It is not known Tamoxifen to cause liver cancer in humans. Sometimes it can cause other liver toxicities in patients, which can be severe or life threatening. Blood tests are usually performed from time to time to check liver function.
I'm sure your sister in low will find Tamoxifen beneficial. There are clinical evidences, about tamoxifen used as adjuvant therapy for early stage breast cancer, that showed reduced risk of recurrence of the original cancer and also reduced risk of developing new cancers in the other breast.
Best wishes!
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lrn10

New User, Becoming EHEALTHy
Joined: 18 Jan 2008
Posts: 1
Tamoxifen
Posted: 01-18-08 06:38am

My mother was taking Tamoxifen for 5 years after having breast cancer. She was just diagnosed with primary liver cancer. It was not metastatic cancer. I believe the tamoxifen caused her liver cancer. She had no previous liver damage. She did drink alchohol but not heavily. I would be careful while on Tamoxifen and make sure to have tests done to monitor how this drug is affecting your body. Another women I know who took Tamoxifen also for 5 years, had to have a hysterectomy due to suspicious changes in her uterus. I think there needs to be more research on this drug.
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jennyr

New User, Becoming EHEALTHy
Joined: 06 Feb 2008
Posts: 1
Liver cancer and tamoxifen
Posted: 02-06-08 03:13am

My mother took part in a tamoxifen trial in the UK. She had had a very early stages lump removed from one breast with an excellent prognosis as it was such early stages.

Anyway, she agreed to take part in a 5 year tamoxifen trial. In the following year after the end of the trial she was diagnosed with cancer. She had multiple liver metastases. They did a liver biopsy but were not able to make a diagnosis of the primary source. She died within 3 months of diagnosis of this incredibly aggressive cancer. Also, while she was on tamoxifen she had to have a hysterectomy (very common as it affects the lining of the womb. Also had cataracts, I think this is common on this drug too.

She was incredibly fit and health with no cancer in her side of the family. Don't risk it. My mother would have been better off not taking tamoxifen. Even if the breast cancer had come back, she would have had a much better prognosis as it's more treatable.
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