Hello dawn, I have not heard of a creme for it. I do not think it would work. I have carpal tunnel in both wrists. I had surgery on my left wrist about three weeks ago. I get the stitches out next week. Believe me if I didn't have the surgery I would still be hurting. They call it a carpal tunnel release. Because it gets inflammed and needs room. I also had to have other surgery on my thumb. I cannot remember to medical term, but what that was, was a pinched tendon. They had to cut the tendon to make room. That was also very inflammed.