"My friend" tried cannabis as well, he cook it slowly in virgin olive oil in microwave to make it edible as he does not like to smoke.
The effects were - increased appetite, decreased pain, anxiety, some clumsiness.
It is quiet effective method to go through an aggravation of symptoms, especially when reduced appetite exist (Dysorexy).
I have met a person who is on appetite stimulant Marinol, (pure TETRAHYDROCANNABINOL) because he was constantly underweight.
I do not think that longitudinal study will be done with cannabis smoking. However, different type of medicine with active ingredients of cannabis, such as Sativex, which is now sold in Canada for MS (multiple sclerosis) pain, could be used in such studies.
Smoking cannabis poses potential liability issues due to carcinogenic effect of smoke.
I do not think any professional medical institution would attempt to use carcinogenic method of marijuana ingestion. However, again, other various methods exist for ingesting, either professional extracted, pharmaceutical grade sublingual Sativex spray, or perhaps some oil suspension of THC for the oral use to allow absorption through the stomach.