A recent blood test showed that my platelets were above normal limits. They are currently at 535 million. I have been lossing hair for several months. It is now noticably thinner although no bald patches. I also have muscle aches and get tired easier. My question has three parts firstly are all these symptoms likely to be linked? Secondly could this have anything to do with my miscarriage in january of this year. And finally what could this be an indication of. thankyou
In humans, a normal platelet count ranges from 150,000 and 450,000 per mmÂ³ (or microlitre) (150â400 x 109/L). These limits, however, are not very strict and a deviation does not necessarily imply any form of disease. Nevertheless, counts over 750,000 (and especially over a million) are considered serious enough to warrant investigation and intervention.
Increased platelet counts (thrombocytosis) can be due to a number of disease processes:
1. Essential (primary) â usually over 750.000/mm3:
a. Essential thrombocytosis (a form of myeloproliferative disease);
b. Other myeloproliferative disorders such as chronic myelogenous leukemia, polycythemia vera, myelofibrosis.
2. Reactive (secondary) â usually under 750.000/mm3:
a. Inflammation â very often the reason;
b. Surgery (which leads to an inflammatory state);
c. Hyposplenism (decreased breakdown due to decreased function of the spleen);
d. Hemorrhage and/or iron deficiency.
High platelet levels (thrombocytosis) do not necessarily signal any clinical problems, and are picked up on a routine full blood count. However, it is important that a full medical history be checked to ensure that the increased platelet count is not due to a secondary process.
You need several laboratory tests (full blood count, liver enzymes, renal function and erythrocyte sedimentation rate) to find out the reason for thrombocytosis. If the cause for the high platelet count remains unclear, bone marrow biopsy is often undertaken, to differentiate whether the high platelet count is reactive or essential.
Thrombocytosis and hair loss could be related to the near miscarriage you had.
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