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Conditions and Diseases > Skin Forum > Systemic mastocitosis
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Q: Systemic mastocitosis
asked by: DoctorQuestion on June 20th, 2009
Can someone please help me! I have something that breaks out on the whole entire skin on my nose for the past 6 years. It comes and goes, when I have a cold, or if I cry or even if I blow my nose with a tissue. This time it came back because I accidently nudged it with my finger nail. It can easily come back. When I know it's coming back it gets itchy, then it get's red, then it starts to break out swollen like small blisters with very little puss or liquid or any thing inside of them. Then it gets worse and stays for weeks maybe even months. I have use almost every kind of creams, medicine, ointments and nothing works. I have gone to the doctors an they did a test and they don't even know what it is. I have never seen anybody else have this infection either. Please help me it's embarrassing having a red nose!!!


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Dr. Goce Aleksovski , MD
replied on June 24th, 2009
Skin Answer A6857


It is hard to say what the blisters are without seeing them. Given the data you provided (itchy, red, swollen skin area covered with blisters after friction), you might be experiencing urticaria pigmentosa. Urticaria pigmentosa is a cutaneous (skin) form of systemic mastocitosis.

Systemic mastocitosis, on the other hand, is a disorder in which too many mast cells are present in the skin. Since the mast cells are related to allergies, when another factor such as friction is present, then an excessive release of histamine from the mast cells and hives might occur. The hives are similar to the one in an allergy, with the difference being that in systemic mastocitosis there is no allergen present to cause the hives.


You might want to visit a dermatologist to confirm or to rule out this disorder. The dermatologist might need a simple skin biopsy as an additional examination. If systemic mastocitosis is confirmed, then antihistamines might be recommended. Please note, that these medications would not heal the condition, but might reduce the symptoms and their frequency.




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