It is hard to say what the blisters are without seeing them. Given the data you provided (itchy, red, swollen skin area covered with blisters after friction), you might be experiencing urticaria pigmentosa. Urticaria pigmentosa is a cutaneous (skin) form of systemic mastocitosis.
Systemic mastocitosis, on the other hand, is a disorder in which too many mast cells are present in the skin. Since the mast cells are related to allergies, when another factor such as friction is present, then an excessive release of histamine from the mast cells and hives might occur. The hives are similar to the one in an allergy, with the difference being that in systemic mastocitosis there is no allergen present to cause the hives.
You might want to visit a dermatologist to confirm or to rule out this disorder. The dermatologist might need a simple skin biopsy as an additional examination. If systemic mastocitosis is confirmed, then antihistamines might be recommended. Please note, that these medications would not heal the condition, but might reduce the symptoms and their frequency.
DISCLAIMER:
"Ask a Doctor" questions are answered by certified physicians and other medical professionals who volunteer
their time on eHealth Forum.
For more information about experts participating in the "Ask a Doctor" Network, please visit our
medical experts page.
You may also visit our Skin , for moderated patient to patient support and information.
The information provided on eHealth Forum is designed to improve, not replace, the relationship between a patient and his/her own physician.
Personal consultation(s) with a qualified medical professional is the proper means for diagnosing any medical condition.