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Synvisc side effects (Page 5)

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January 26th, 2012
I had my first Synvisc injection right before new years 2010. Two days later, spent that new year's eve having knee surgery! It was infected. Dr, didn't know if it was the batch or what, but I ended up having to have a pic line and IV antibiotics (2 different kinds)twice a day for 6 weeks! Needless to say, have not had any followup injections. Right knee still swells and becomes rather painful.
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replied September 12th, 2012
I am so sorry about what you went through. Are you OK now?
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replied March 26th, 2012
muscle aches after synvisc one injection
I recently had my 1st Synvisc One injection, in my right knee. (I tried Supartz once, without relief, but have since-2 yrs ago- had a partial meniscectomy for a torn meniscus.) The injection itself went well, but the night after the Synvisc injection I had SEVERE muscle aches in both legs from my hips to my ankles.This lasted about 24 hrs and eventually subsided. Has anyone else experienced these severe aches?
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replied September 12th, 2012
Wow, I cannot believe what I am reading on this site. I have Rheumatoid Arthritis and Osteoarthritis in my left knee. Roughly a year ago, I had surgery for a torn meniscus. I chose to get the Synvisc One injection becuase the arthritis under my knee cap is severe causing me to use a cane and take high doses of Prednisone. My knee gradually swelled up, I had muscle pain from my left thigh to my left calf down into my foot and where my leg joins my foot. Nothing helped the pain and after 4 days became unbearable. Today I had my knee drained and I swear it looked the same color as Mountain Dew. It's been sent out for testing. I then received a cortisone injection and felt 90% better.

I need another surgery like I need a hole in the head. I am told that maybe I should try Euflexa. I am reluctant to do any shots again but a knee replacement at 50 is a bit much.
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replied June 21st, 2012
I had a synvisc injection last Friday. Within a couple of hours my right knee was double swollen in size. Would not bend and warm to the touch. I immediately looked up the synvisc side effects, looks like I am not alone in this situation. It is terrible to be on crutches and having to wait for this to go down. It really helped to find this forum, thank you for all the advice. My doctor did not want to drain it. By the way, this was my second injection after four years. Had the left knee done also this time but it is barely swollen. It was a first for the left knee. This was a Synvisc One injection. Lot of pain over the weekend. I do not want surgery so I will pray this gets better. Shocked
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replied September 12th, 2012
I already posted above but wanted to see how you ended up doing? I forgot to add to my above posting that I not only had tremendous pain and swelling but could hardly walk and contemplated the ER. I hope you are alright and I hope my tests from the drain are alright. All they asked me is if I had a problem with chicken products. Gee, maybe they need to ask a few more questions or have a allergy test kit.
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replied September 29th, 2012
Synvisc 3 Injections- Extreme Stiffness
I had the 3 injections of Synvisc in both of my knees. I had my last injection a week ago. I do not have much pain in my knees, but I have ALOT of pressure in my knees and when I sit for 5 minutes or more my knees are very stiff and feel like they lock up. After I start moving, I can move a little better but I am concerned about the extreme stiffness and the feeling that my knee is going to explode sometimes after I have walked for a while. I have tried to take a walk around my neighborhood, about 1 mile, but by the time I get home my knees are so "full" that I can hardly move. Anybody else have this problem. Is this only temporary or will it last?
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replied September 29th, 2012
Synvisc 3 Injections- Extreme Stiffness
I had the 3 injections of Synvisc in both of my knees. I had my last injection a week ago. I do not have much pain in my knees, but I have ALOT of pressure in my knees and when I sit for 5 minutes or more my knees are very stiff and feel like they lock up. After I start moving, I can move a little better but I am concerned about the extreme stiffness and the feeling that my knee is going to explode sometimes after I have walked for a while. I have tried to take a walk around my neighborhood, about 1 mile, but by the time I get home my knees are so "full" that I can hardly move. Anybody else have this problem. Is this only temporary or will it last?
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replied September 29th, 2012
Synvisc 3 Injections- Extreme Stiffness
I had the 3 injections of Synvisc in both of my knees. I had my last injection a week ago. I do not have much pain in my knees, but I have ALOT of pressure in my knees and when I sit for 5 minutes or more my knees are very stiff and feel like they lock up. After I start moving, I can move a little better but I am concerned about the extreme stiffness and the feeling that my knee is going to explode sometimes after I have walked for a while. I have tried to take a walk around my neighborhood, about 1 mile, but by the time I get home my knees are so "full" that I can hardly move. Anybody else have this problem. Is this only temporary or will it last?
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replied October 4th, 2012
I had Synvisc One injections on both knees 6 days ago and within few hours of the injections, my left knee became stiff and very painful. I cannot bend, cannot straighten the knee and cannot put my weight on it. If I sit or keep my knees immobile for ten minutes, it became very painful to move. I called my doctor immediately and he gave me painkiller, arcoxia, steroid and a jab for the allergy he said. But it's been 6 days, and my left leg is still sstiff and painful and my ankle is swollen. I've had several Synvisc injections in the past 4 years, but only this time I experience such bad reaction. That's what brought me to this forum. When I read through the forum, I'm surprised at the number of people suffering the same side effect; and more surprised that doctors still recommend syndvisc, without honestly and openly explaining the high level of probability of suffering the side effect. So what now? What other medications, sans surgery, do AO sufferers have?
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replied December 10th, 2012
Knee blew up on third Synvisc injection- placed on steroids
Help!!! I had my third synvisc injection and my knee blew up. The swelling was so painful that it felt like a tennis ball was behind my knee and that there were rubber bands strangling my knee. I couldn't bend it and was hobbling. After a week of this not getting better I went back to the orth doctor. He told me that it was very rare allergic reaction and ordered a 21 day steroid blister pack. He said that the third injection is thicker than the other two and that's what I reacted to. I had synvisc injections in both knees but only problems in one knee and had the same thing done to both knees 8 months ago with no problems. I called the manufacturer and they said all three injections have the exact same ingredients, volume and consistency and that they will be sending my case over to product safety for a reply. Any help would be appreciated.
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replied April 25th, 2013
Day three of last injection
I have had Synvisc injections for about 3 years now. A few times I had swelling and pain. This time I have a lttle swelling but the pain down the side of my leg is almost unbearable. I have a VERY high tolerance to pain and this time I had to dig out my Vicodin to try and ease the pain. It has been 3 days now and after I walk I have to massage the side of my lower leg. He did give the shot on the outer side of the knee this time. Does anyone else have trouble with pain down the side of the lower leg with their injections?
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replied June 7th, 2013
I see many people have made comments but see no followup replies as to how it all ended for you? I had both knees done yesterday, woke this am with tightness and swelling. Had to take my first son to enter MSU, needed a wheelchair to get around campus! It was hard to find a good site that had realistic truths about synvisc.
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replied September 13th, 2013
Synvisc One adverse reaction
I'm having problems with a left knee as I had a bi lateral done on Aug 19th. I had previously only done the left knee last Nov 2012 with no major problems except at the injection site which now that I think of it, always stayed sore. Fast forward, my left knee was tight and swollen. I had 30 cc's drained out several days after injection and a steroid shot. Felt much better, then more days went by and knee became stiff again, this time though my left shoulder feels like frozen like I just had surgery. Had knee injected again and felt better, should feels 98%! Today about 7 days later the knee is tight and BOTH my shoulders are bothering me. Particularly the left. It's worse when I lay down. I'm very concerned and will be calling my ortho today. I just want to go back to my "normal" self. I live alone and depend on no one. I'm 59.

Edit update: All shots were 6 cc's.

Went back to my ortho and had another anti inflammatory shot. No steroid, not much to drain, so he didn't drain.

Fast forward, my L. Knee is swelling again.

I called this past Thursday and ortho secretary said I should get checked out my primary doc and be evaled before coming back????

So, I went to ER, They Xrayed and they gave me 4 days of Prednesone and Oxycontin.. Shoulders feel a lot better. Tommorrow is last dose. I'm worried what will happen Monday. But I'm going back to see the ortho Monday and demand he drain the puffy fluid that is building up (again). I'm going to ask that he culture the sample to decifer if it's an allergic reaction.

I also had a physical on Aug 5 and my CRP score was 4.5. Shots were done on 8/19. The ER took blood this past Thursday and the CRP score is now 27????

I also have a Holistic doc and he recommends I see a Rhuematologist. I see some mention immunology. What to do??????

I PM'd "BANSYNVISC" but if anyone who has gone a long time out from this ordeal and cares to email me directly, it's .

I'd really appreciate advice and feedback. My ortho is still in denial.


Brian
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replied September 22nd, 2013
Possible reaction to SynviscOne
I had my left knee done NOV 12. Full dose. No problem.

I had both knees done Aug 19 THIS YEAR. Left knee reacted. Full dose.

About 9 days later, my shoulders were absolutely frozen. I was in a lot of pain to roll over in bed at night.

Doctor drained 30cc's and gave me a steroid shot. Odd thing, my shoulder pains completely went away for about 5 days, then knee and shoulders acted up again.

Several more days later, I went back and had another anti inflammatory shot. No steroid, no heavy fluid build up was present, so I just got the anti inflammatory shot.


Knee flared up again last Tuesday and continued to build up pain.


Last Thursday, I went to local ER, They Xrayed knee, shoulders, and they gave me 4 days of Prednesone and Oxycontin.. Shoulders feel a lot better. Tommorrow is last dose. I'm going back to see the ortho Monday for an eval.

I also had an annual physical on Aug 5 and my CRP score was 4.5. Shots were done on 8/19. The ER took blood this past Thursday and the CRP score is now elevated probably due to inflammation?

I was advised to see a Rheumatologist recommended to me by my Holistic doc for this mysterious problem. Unfortunately, it’s the weekend and I’ve not yet made contact with this type of doctor yet.

Update: It’s 4:30 am EST, I’ve been woken up by knee pain this time on the outside of my knee joint. My shoulder is acting up again and I just took my last prednisone that was prescribed by the ER doc in charge and one pain pill.

Will see what eval brings on Monday.
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replied October 4th, 2013
Synvisc reaction
Both my knees need to be replaced (bone on bone) and I have SEVERE fibromyalgia and Sjogren's Disease. This makes me a poor candidate for surgery.

I have been receiving Synvisc for years. My last injections (7 weeks ago) were a nightmare. After the injections both knees presented with a severe effusion reaction. My left knee had to be drained (a LOT of fluid). I was on a walker for a week as I could not use my left knee for support and it did not bend. It actually felt as if I had no knee!

After that, I used a cane for two weeks. As I have constant pain in my fingers, this was most unplesant. Both knees were excrutiatingly painful. The swelling, redness and heat are finally gone, but both knees hurt more and in additional locations than before the injections. My ability to walk has been further curtailed.

I have also been having hard chills...without the chill part (no sensation of cold),which is very bad for my fibro. I have developed brand new joint pain in both hips. My other joints (those which are old companions in pain) hurt more and all the time.

I also have a sore throat, which happens sometimes wtih my fibro, but not usually for so long. I have felt like roadkill since the shots and been in the longest severe fibro flare of my life.

I will not take the Synvisc again.
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replied October 4th, 2013
I am currently under the care of a Rhuematologist. He's drained the knee 3 times now and gave me some cortisone. I'm 6 weeks out. My shoulders froze up on me again 2 nights ago and my knee was KILLING me. I have just finished a 5 day pack of Prednisone which kept my shoulders moving. He now has me back on Prednisone 5 mg 2x day and careful watching. I advise you to see a Rhuematologist. I"m told Synvisc sometimes goes haywire on someone AFTER the 2nd time or beyond that a joint sees it.

I'll try and post further progress as it happens.
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replied January 13th, 2014
This is a continuation of "My story". Mid October, I called my ortho because I was still out of my mind in pain/swelling and wanted an MRI, my ortho said I needed a new knee and I was in denial, I ended up just hanging up and found my Rhuemo and I got a cortisone shot in my knee and it felt GREAT for about 3 weeks. He also Xrayed the knee and said it looked great compared to what he sees in his office. Most of the people in there were 15 years older than me. He said in his opinion, he didn't even think he would have treated with lubricants.......So, I've fired my ortho of 20 years and I also found a new ortho doc in November, who DID an MRI and found torn meniscus cartilage and scheduled surgery for 12/30. All the time leading up to surgery, I was dragging myself into work, taking pain meds, Ibuprofen, and only missed a day or two. I was also never able to squat down (not even close) or flex my knee literally from September onward. Well, I am post op now and dealing with post op swelling.I had tried to go with no Meds after a few days post op because I had irritated my stomach during those 4 months of HELL taking all kinds of stuff. I had my first PT session last week but bending and flexing knee really hurt and I also seemed to have developed a bit of high blood pressure now. The stress I experienced through all of this has been "epic" and I'm sure it didn't help anything....I started taking Aleve yesterday and it really helped with the swelling but the minute 12 hours are up.........so for the moment, that's where I'm at, 14 days Post op. I think Synvisc is only suitable for captured Al Queda operatives...........
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replied January 10th, 2014
I also had a series of three Synvisc shots in each knee. They helped a lot with my knee pain. Six months later I had a second set of three in each knee. No problems. Then 8 months later I had a third set of three in each knee. The second one didn't feel so good. Then the third shot sent me into pain, swelling and redness. I could hardly walk! I called my doctor and he gave me a steroid PAC that immediately cleared up my symptoms. NEVER again will I take these. The Dr. said that I had developed an allergy to the Synvisc shots.
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replied January 20th, 2014
Caroynn,

What's a steroid PAC?
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replied May 23rd, 2014
Re: synvisc side affects
billsout wrote:
just had synvisc injections in my right knee! has any one had a side affect of complete engery drain...weakness
'

same here, glad i had a driver
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replied May 23rd, 2014
not a lot of new posts here. i had synvisc-one injection two weeks ago. i'm still having some swelling in my knee and it still grinds (love the sound, don't you?). however, i am reading that it takes up to a month for the full positive effects to be felt. anyone who is a month out from injection have any info?
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replied October 16th, 2014
Synvisc reaction pain and swelling
I have been suing Synvisc injections for over two years but the last time I had the injections I could not walk the next day. My knees were swollen and I could not bend or fully extend either leg. I required help just getting down stairs or out of a chair. It is better now after 2 weeks but I still can not walk without pain. I do not understand Synvisc worked so well for over 2 years and then really bad pain and swelling
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