I had similar, less severe, but chronic symptoms. Swollen hands, rash, anxiety, etc.
It turned out I had a food allergy to wheat! It's different from a gluten intolerance (celiacs disease) mostly in symptoms. If you have a food allergy it could be to anything: egg, nuts, soy, milk, and corn are some of the most common.
Has your diet changed lately? If these problems persist, see your doctor to have an allergen test done so you can change your diet accordingly.