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Swelling and numbness in patients with renal disorders (like chronic kidney disease), can be a sign of fluid overload and electrolyte imbalances associated with worsening kidney functions.
In such situation appropriate changes in dosage of current medications or addition of newer medications will be necessary. In severe cases, regular dialysis might also be necessary. You might consult with your doctor or a nephrologist at the earliest for a examination and proper advice and treatment.