spots deep under the skin and feel as big as a fingernail

Hey, simple question involving spots. I'm 21 and over the past couple of years I've started to get quite a lot of spots on my face and upper back, which I never had as a teenager. I thought I was the lucky one out of my friends for not having any, but it seems to have caught up with. I've tried using near enough every cream and face wash on the market, things like Clearasil Ultra Deep Pore Treatment to Freederm gel to Panoxyl Aquagel 10 and most recently Panoxyl Aquagel face wash, yet they still appear. Nothing seems to work. They're not just simple little spots either that you could pop and be rid of, they are always deep under the skin and feel as big as a fingernail in size under the skin. I only ever seem to get them around my nose, mouth and chin area on my face and in the same places each time. Any help at all would be amazing.