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Q: small cell lung cancer
asked by: Vieklenz on September 15th, 2008
New User
Hi everyone. I've been lurking on here since Jan. and decided to open up a bit. My mom went into the hospital Jan. 25th with what she thought was the flu. After 5 days in the hospital and numerous appts. with a lung specialist we were given the news of extensive small cell. It was in both lungs and two lymph nodes. She started chemo right away. Etopocide and carboplatin. She handled both really well in my opinion, just a case of fatigue but nothing too drastic. The first two rounds went great and the follow up petscan showed that it had wiped out 3 of her 5 tumors. SEcond two rounds...not as great but not bad either. The remaining two tumors were still there but no change. Third set of treatment didn't work. There is now a new tumor on her left lung, 3.5 cm x 2cm. So the doc was hoping to give her a chemo break but decided against it at this point. She will now be taking topetecan once a week for the next 8 weeks. I know not everyone is the same and we will all react differently but does anyone have any experience with this chemo? I have read up alot on this nasty, ugly cancer and I pretty much see the road we are headed down. So, I don't expect sugar coating. I like to be prepared. My mom on the other hand doesn't want to know anything. That makes it a bit hard when she is constantly saying she doesn't understand why the chemo stopped working. Anyway, thanks for reading if you got this far. I hate that there has to be a forum for this...but it does help in a way.
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MandMs
replied on September 16th, 2008
Extremely eHealthy
I'm sorry for your mum!

Topotecan is always considered the standard first-choice single agent for the treatment of relapsed SCLC (cancer that hasn't respond or came back after the first chemotherapy regimen)
Also, topotecan is an effective treatment in patients with poor daily functional status, patients that might otherwise not receive chemotherapy.
There are different schedules for Topotecan administration, but, the weekly one as in your mother's case is the most studied and is generally well tolerated in patients who have relapsed SCLC, with less blood toxicities, and other rare severe toxicities.

Best wishes!
Marija
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