Over the last 5 months I've had two sets of tests done and my Antibodies to double-stranded DNA (anti-dsDNA) levels were high in the first test and then went up even more five months later. My doc says that this may indicate SLE... Along with the results I have chronic fatigue, horrible headaches, swollen painful joints, trouble sleeping, depression, I battle with my stomach, sores in my mouth, occasional episodes of vomiting, I have recently been diagnosed with asthma so I have a cortisone inhaler, and of late I have been suffering with chest infections and strep throat. So if not SLE, then what?
Thanks so much
Hi, welcome to the ehealth forum and I am glad to help you.
You seem concerned by the high titres of anti-ds DNA levels suggesting the diagnosis of SLE. You have also made a mention of chronic fatigue, headaches, swollen painful joints, trouble sleeping, depression, stomach upset, sores in mouth, occasional episodes of vomiting, asthma, chest infections and streptococcal throat.
Complete saturation of protamine sulphate by dsDNA is necessary in order to obtain a highly sensitive and specific anti-ds DNA ELISA test. This is to reduce interference by other autoimmune diseases in the diagnosis.
Anti-double stranded (ds DNA) antibodies are of considerable diagnostic value and are thought to be involved in the pathogenesis of systemic lupus erythematosus (SLE). Fluctuations in anti-dsDNA antibody levels are also used as markers for disease activity and exacerbations. Anti-dsDNA antibodies are present in SLE patient sera much earlier than previously suspected. In addition, there is evidence for increases in anti-dsDNA levels contributing to the onset of clinical illness in some patients with SLE. Similar seems to be the case with you as you have also recorded a rise in anti ds DNA levels.
Other possibilities that need to be ruled out include leukemia as you have a family history of the same and also HIV if there is history of risk exposure as the symptom complex in you can also represent HIV infection. Still the possibility of SLE is the strongest because of rising anti ds DNA antibodies.
Hope this helps. Take care.
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