Kidney enlargement or a swollen kidney is more commonly due to obstruction of the urine flow, which can cause dilatation of the renal pelvis and in severe cases dilation of the kidney itself. The condition is called Hydronephrosis.
Normally urine flows out of the kidney with low pressure. If this flow pattern is disrupted by dilation of the kidney placing increasing pressure on the delicate internal structures of the central urine collecting system, damage can result through loss of function of the kidney.
Since this is a anatomic issue, medications usually are not helpful to cure the condition. Medications may be used only to treat symptoms or complications (like infections) associated with the condition.
Other possible causes of kidney enlargement include - Cysts, tumors, systemic disorders like amyloidosis, etc.
Hence it would be recommended that you consult the treating doctors (Urologist) and seek proper advice and help.
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