This could be some kind of infection, like scabies, but, it is far more important for your father to be checked for Hodgkin's lymphoma and other lymphomas, because they may manifeste with symptoms like nights sweats, fever at night, weight loss, skin itchiness, especially at night, skin rash, cough, feeling fatigue.
Itchiness from scabies is also more prominent during sleep.
He should visit his physician!