As all of the clinical data in this area is retrospective in nature, I can only comment on what has been published tgus far. Most of these studies show no significant increase in the risk of congenital abnormalities in children born to women who have previously been treated with chemotherapy and intracranial radiation therapy for leukemia. Likewise, the rate of leukemia recurrence following pregnancy appears to be relatively low (although there is always a small risk of delayed recurrence of leukemia, with or without pregnancy).

You should , of course, discuss your concerns with both your oncologist and your gynecologist, before deciding to try and have a child. Based upon the available evidence, however, it would appear to be reasonably safe for you to become pregnant if your have been in complete remission for the past 10 years. If you do decide to become pregnant, then you will have to be carefully monitored for any signs of ALL recurrence during and after your pregnancy;.

Sincerely/ Robert A. Wascher, MD, FACS

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