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Prednisone and bi-polar disorder

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My father has been diagnosed with bipolar disorder. He recently developed pneumonia and was taken to the emergency room and was given prednesone. He is now manic. Is there anything that can be done to counteract the prednesone? Would taking more depakote help? He has a time-realease depakote that he takes daily. Thanks for your assistance.


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replied May 5th, 2008
Bipolar Disorder Answer A4038
There are data that prednisone can cause mania as a short-time side-effect but very rarely. Maybe the possibility for such a side effect occurring is bigger in patients who are already experiencing manic-depressive disorder (bi-polar disorder). We can’t be sure if a manic episode occurred because of the prednisone or because of the disorder itself. Prednisone can be replaced by another corticosteroid drug.


You should consult a psychiatrist about any changes of Deprecote dosing .



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