Well, plan B is a high dose of hormones that can seriously mess with your wife's cycle.
Side effects are pretty normal with Plan b. Some of the common side-effects are: headaches, cramping, nausea, fatigue, and breast tenderness. She will probably experience some irrgular bleeding or spotting for up to three months too. It's really hard to say what side effects she'll get since it's different for everyone.
Her period may be early or late, and it could also be heavy or light. There is also a possibility that your wife is very lucky and her period stays the same. Either way, as long as there's a period then you're usually in the clear.
If her period is late, then take a hpt to be safe.