Can herpes be responsible for lesions of the brain?
Answer: No (not that I am aware of)
Can MS explain the mass of inflammation on my lower spine?
Answer: Is it a mass or lesion(s)? If lesion then yes that can affect your ability to walk.
There is a history of Lupus in my family, is that in the same family as MS?
Answer: MS and Lupus are both auto-immune diseases...
What other reasons could explain the lesions on the brain?
Answer: Migraines, stroke, tumor, MS (ones that I know of)...