Modafinil and Liver Enzymes

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Liver enzymes include aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT). These enzymes are normally contained within liver cells. If the liver is injured or damaged, the liver cells spill these enzymes into the blood, raising the enzyme levels in the blood and signaling liver disease.

ALT (also called alanine aminotransferase or SGPT) is found in the liver only. The normal range ‎‎of ALT levels is between 5 IU/L to 60 IU/L. In your case, the enzyme level is severely increased.

Modafinil is usually not associated with change in liver or kidney parameters. Most common medications that are associated with liver damage include - Statins, NSAIDS, antibiotics or antiseizure medications.

You might consult with your primary care physician, and undergo tests including a ultrasound and a hepatitis panel of tests to diagnose the cause of your liver dysfunction. A review of other medications , that you may be on, also would be very helpful.