First and foremost, skipping a period is not necessarily uncommon when a woman takes any type of birth control. And actually, Loestrin Fe boasts a "3 day or LESS" period, so it does not surprisingly that you miss them occasionally. Stress commonly is a factor to missing periods (ain't that screwy- since you stress over missed periods and that can actually aid the problem!?). If you're worried about being pregnant, take a test. Wait a couple days and take an early test. And I know...waiting is not something you want to do when you are really nervous, but honestly...is anything going to change in the next couple of days?
About the acne...the FDA has approved Loestrin Fe to treat acne. However, if it's not working for you, talk to the doc next time you're in. There are hundreds of different types of birth control because women react differently to them. So, talk to your doc about treating the acne and making the period a little more regular/less mysterious.
Good luck!