I'm sorry your brother is facing such a difficult disease.
Cancer itself leads to fatigue, or tiredness.
Although, the growth of cancer is inhibited, the already existing cancer cells use up much of the bodyâs energy supply or release substances that change the bodyâs metabolism. On the other side, the cancer patient have lost weight and have decreased appetite, so, there are low energy sources.
Also, the cancer may cause the immune system to react in ways that produce fatigue as a symptom.
Fatigue may be an important symptom as cancer progresses.
Feeling tired is a side effect of using Nexavar, too.
Having fluid build up in abdomen can lead to swollen testicles.
Sudden swelling, yellowing of skin, are signs that the cancer has poor prognosis.