Has your daughter had a recent EEG? The behavioral changes, depression, anxiety and aggression can all be symptoms of neurological changes secondary to subclinical seizure activity. Perhaps a visit to her neurologist is in order. Sometimes hormonal changes can trigger seizures. Have you seen any staring, calling her and she does not respond (I know - what kid doesn't do that), daydreaming, confusion? These are symptoms of seizures.

Sorry I can't tell you more. Your daughter needs an EEG and to be assessed by her neurologist.

holdu, Has your daughter tried Depakote. I take 2,000mg a day. I noticed a little weight gain but not to much else. I had the same side effects as your daughter but I was on Topamax. I have had JME for 12 years. I went 7 years without having an episode on Depakote. But when I started to change around my meds the JME broke through. If you find something that works stick with it.