Yes I have dull dim vision and eye pain but I have had PRK surgery for vision correction and had very scarred corneas prior due to Sjogrens and have dry eyes. My blurred dim vision started over a year ago after being on plaquenil and I feel it has something to do with my nervous system. It started way before being on Isoniazid. It actually isn't worse on Isoniazid. I use restasis drops (cyclosporine) but stopped before therapy and switched to saline and ointment. I'm cutting back on any drug not absolutely needed while on the Isoniazid.
The black spots, sort of shadowy hallucinations usually occur at night, in peripheral fields and is exactly what happened before going on thyroid therapy. It completely went away with proper thyroid supplementation. Now it is back on the isoniazid so I wondered if it was due to the isoniazid affected the synthroid.
MY TSH had been at 1.8 for over a year now or more since I've been on synthroid. In March it had gone up to the 2.7 but I didn't start Isoniazid till June, so it was already going up and the endo said it would as my thyroid kind of slowly dies.
Thanks for letting me know about the synthroid being affected by the isoniazid so I can make sure the endo knows. My synthroid likely needs to be raised, but it could go back down, since my thyroid is so unstable and it depends on my autoantibody loads, it can go up and down like crazy and be irritating. I wish they'd just take it out, but they don't want to since it works halfway still. Usually it is stable, but the isoniazid is a strong drug.
Yes the black dots or irregular patches move in my field of vision. Sometimes they look like hands or arms, or a cat jumping or just something not explainable. The mind tries to make sense of them. There is some anxiety with the "shadow men" because you have to keep reminding yourself that it's just light and shadow play, but it startles you a little before your intellect can kick in and deal with it.
My vision looks like I have eye ointment in all the time with some dimness, but that is old. I have to get back to the eye doc, I have a referral sheet for my next visit so maybe this is the time. I want to get my thyroid results soon, I should have them tomorrow or Monday, and it will have my liver too, and then I can call the endocrinologist and the eye doc and have the results.
I have found relief cutting out red meat from my diet and avoiding the foods on the tyramine list and have ordered some high quality whey protein vitamin powder to provide good nutrition to cut back on meat just to give my liver a break. I'm also eating probiotic yogurt which has been shown to be as effective as lactulase in recent studies and helps my gi. So hopefully with diet modifications, even someone like me who has real problems with drug metabolism due to severe steatohepatitis can make it through therapy.
Avoiding meat has been surprisingly helpful. and the aged cheese. Smoothies are working good, and much smaller portions of regular food.
Thanks for your help on everything.
Yeah sometimes my legs tremble or are numb or tingly, but it isn't every night or even long lasting, so I'm not so worried about it.
I've got dizziness, a feeling like I inhaled fumes or something at times, but it isn't constant. Increasing my klonopin from 1mg at night to 1.5 mg has helped with anxiety and some of the neuropathy. Taking my vicodin ( I take one pill split in half in two doses) earlier in the day, not morning and night, helps too.
I take B6 50mg and get half the daily requirement in the whey mix.
I hope I get my latest labs soon. I am allowed to let my liver function tests go five times normal before I have to go off Isoniazid. We agreed that some fibrosis is worth getting through the therapy and will likely mend once I'm finished.
Thanks so much for your answer on the syntroid and also the glucophage. Sorry so rambling, I'm like a puppy, all over the place lately. In a way, its nice to have so much more energy than normal. I have been much more active and during the days. I take my isoniazid at dinner time and have the worst effects during bedtime during the first few hours after I take it.
I won't alter my dose, but just FYI, my mother asked if it might be better for someone like me with a bad liver to split the tablet in half and take one in the morning and one at night, to lessen the effects. Does anyone ever take it like that?
It might be easier on my liver, though I take four pills in the morning and to take another, I would have to space it out well.
Thanks so much. You are such a help. I feel better and know what I need to do. I have two endos, one at Mayo and one close to home. Sometimes the one close to home isn't as responsive as the one at Mayo, so I needed to know kind of what direction to go. Thanks again.
