In general, any pigmented lesions (including moles) that change in size, shape, or color should be biopsied. Similarly, any spontaneous bleeding or itching associated with a pigmented ski lesion should also lead to a biopsy, to rule-out melanoma.
Sincerely,
Robert A. Wascher, MD, FACS
www.doctorwascher.com
Author, "A Cancer Prevention Guide for the Human Race"