is it safe to use estrofen for more than 12 years?

eda,

There are risks in taking hormone replacement therapy and the longer you take it, the higher the risks. However, each woman's risk-to-benefit ratio is different. This is something that you need to discuss with your physician, who knows your past medical history.

There is a very long list of possible risks and side effects of taking hormone replacement therapy. But, again, what would apply to one person may not apply to you. So, when reading about the risks of HRT, you must take your own situation into account. This, again, is why you should speak with your physician about your concerns.

Good luck.

Thank you very much! I'll arrange an a appointment with my gynecologist very soon.
Thanks again.
Eda