My doctor put me on Prilosec 2 x a day for ulcers & reflux.
I take one when I get up at 7:30 am with my cup of coffee and one at 7:30 pm an hour after dinner.
I have done so for a year and the prilosec is working fine.
I know i'd be better off with no coffee in my diet, but that is not going to happen.
The only question is, does it hurt anything to take it with hot coffee?
At night I take it with a 1/2 a cup of 2% milk.