I have inflammatory arthritis and have tried Enbrel, (no relief!) for eight weeks since pain is primarily in my back, wrists, hips and knees. (Rhuemmy is thinking AS) I have now switched to 6 Methotrexate weekly and 5 mgs of Prednisone daily and am still in significant pain since the switch over in mid October. I certainly would hope it would have started to show some sign of working by now! This lovely disease has affected how I do everything in my life, and I just want to find some relief! Anyone had any experience with this drug combination and it's effectiveness?