How do I break my wifes low self eseem cycle.

How do I break my wifes low self esteem cycle. This is my diagnosis as she feels happy behind her wall of symptoms. She is a hypochondriac spending much of her day laying on the bed "feeling poorly". She has some electronic gadget which she holds permanently on any part of her body which she thinks is ailing. She has no job nor interests other than watching television. She only comes out of her mood when there is something to look forward to like a holiday or wedding. She does not join in any conversation until she gets to know the person very well - and then forcefully gives them advice usually on subjects in which she has no knowledge. She is extremely untidy, and her own room is a total mess - however she will not go out of the house, even to the garbage dump or supermarket, without an hour in front of the mirror, high heels and a handbag. In a group she is a shrinking violet until the spotlight is on her then she goes crazy and plays to the audience. She worries constantly about anything and everything and I feel this limits her ability to enjoy life. So my diagnosis is low self esteem - my question is how do I tackle it without causing it to become even lower ??