My mother who's in her 60s has been taking supplements for a while now from this company called "GNC" and I want to know if the combination of the following supplements that she's taking will not have any adverse side-effects to her.

Here are the supplements:

Milk thistle
Colon Cleanse (a fibrous capsule) w/ Selenium
Triflex Glucosamine
Gingko
Zinc
Calcium Citrate
Flax seed
Calcium Citrate
Fish Oil
Vitamin B
Bilberry
Magnesium
Ascorbic
Digestive Enzyme
Alpha Lipois
Taurene
Chromium Picolinate
Evista (Raloxifene)
Black Cohost

Is this combination harmful? She's been taking this for a while already and we have been wondering whether this is ok or not.

EDIT:

Almost forgot. She's also taking Evening Primrose Oil capsules s well.