as you work at a desk and are a smoker working on your health and fitness should be your priority.
popping pills, shakes, low fat meal replacements are all gimmicks that whilst they sometimes work in the short term will not support maintenance of a long term healthy weight and body.
If running is a challenge try a different form of exercise or activity, one that you enjoy.
As a fitness professional it truly pains me when people are mislead into using "fat burner" miracle products when the companies have no concern for your health...
I wish you all the best with your weight loss but please consider your health first...the weight will take care of itself