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It is very hard position to be in pain and not get any relief from medications.
In case, you have severe debilitating pain and joint destruction from arthritis, then in addition to pain killers and immunosuppressive medications, Injection of steroid injection, within the joints may be helpful to reduce the inflammation.
In addition, you should also consult with your doctor or a orthopedician, with the possibility of joint replacement procedures, which may be the best alternative, as it will remove the source of pain and also improve the joint mobility and quality of life.