HELP, I am 63 and was diagnosed with cll 3 yrs ago, now my spleen it very enlarged but my INR is 7 and they cannot operate. I have low platlets and hemoglobin, my hemotoligist says i have an antibody in my blood but does not know what is wrong, does anybody have any answers, had bone marrow biopsy and it was normal, however I have had several false positive on infectious diseases, my spleen is so enlarged i have trouble breathing, anybody else have this??
Most patients with CLL tend to develop increased production of abnormal antibodies which can produce variety of signs and symptoms.
In your case, anti platelet antibodies are being produced in the body, which are destroying the platelets, hence the cause of low platlets and hence defective blood clotting. Such condition is termed as Idiopathic thrombocytopenic purpura (ITP).
Idiopathic thrombocytopenic purpura or ITP occurs when certain immune system cells produce âââantibodies against platelets. In such a situation the possibility of increased platelet destruction due to âââpresence of antibodies to platelets results in low platelet counts. â
Treatment of ITP is usually symptomatic and the only thing needed is time and patience. In some âââcases, steroids (like prednisone) can be started to help in recovery. In resistent cases, âââimmunosuppression can be helpful. â
The difficulty in breathing in your case can be due to the severe enlarged spleen, affecting the lung expansion. You may consult with your doctor or oncologist and seek his advice regarding therapeutic splenectomy, to help your current condition. âSubstantial improvements in hemoglobin and platelet counts are observed in up to 90% of patients undergoing splenectomy.
I finally got diagnosed, ITP, Evans syndrome, lupus antiocoagolant, cll, started prednisone and feeling better, spleen not as swollen, my doctor thought and hoped a round of pred would get me in remission, however while tapering off the pred all my symptoms came back, i only missed 2 days of 10mg of pred and this happened, got blood checked and all numbers decreasing, my next step is Rituxan and hoping that will work. I am a 63 yr old male and want to know if there are anymore adults with Evans, I have seen alot about it in children but not adults. Thanks for the response.JB
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