enlarged spleen and blood not clotting

Hello and welcome to e health forum.‎

Most patients with CLL tend to develop increased production of abnormal antibodies which can produce variety of signs and symptoms.

In your case, anti platelet antibodies are being produced in the body, which are destroying the platelets, hence the cause of low platlets and hence defective blood clotting. Such condition is termed as Idiopathic thrombocytopenic purpura (ITP).

Idiopathic thrombocytopenic purpura or ITP occurs when certain immune system cells produce ‎‎‎antibodies against platelets. In such a situation the possibility of increased platelet destruction due to ‎‎‎presence of antibodies to platelets results in low platelet counts. ‎

Treatment of ITP is usually symptomatic and the only thing needed is time and patience. In some ‎‎‎cases, steroids (like prednisone) can be started to help in recovery. In resistent cases, ‎‎‎immunosuppression can be helpful. ‎

The difficulty in breathing in your case can be due to the severe enlarged spleen, affecting the lung expansion. You may consult with your doctor or oncologist and seek his advice regarding therapeutic splenectomy, to help your current condition. ‎Substantial improvements in hemoglobin and platelet counts are observed in up to 90% of patients undergoing splenectomy.

I finally got diagnosed, ITP, Evans syndrome, lupus antiocoagolant, cll, started prednisone and feeling better, spleen not as swollen, my doctor thought and hoped a round of pred would get me in remission, however while tapering off the pred all my symptoms came back, i only missed 2 days of 10mg of pred and this happened, got blood checked and all numbers decreasing, my next step is Rituxan and hoping that will work. I am a 63 yr old male and want to know if there are anymore adults with Evans, I have seen alot about it in children but not adults. Thanks for the response.JB